A delay in dissolution or insolubility had occurred in the past with the capsule shell, which is mainly made of gelatin, due to reactivity with certain inner fill material.
	Aldehyde functional groups that exist in inner fill material form bonds with amino acid residue of the gelatin, and the resulted cross linkages cause insolubility of the capsule shell.
	Tokai Capsule has been dedicated throughout the years to the research and development of succinated gelatin capsules that readily dissolve without causing delayed solubility. Succinated gelatin is derived from a reaction between gelatin and an organic acid, succinic anhydride, and amino acid residue in gelatin is substituted with acidic chloride.
	Theoretically, any organic acid can be used for this particular reaction. However, succinated gelatin derived from using succinic anhydride is the most suitable for production of soft capsules. This succinated gelatin that readily dissolves and does not delay its dissolution is equivalent to regular gelatin in terms of elasticity, adhesiveness, and viscosity as a gelatin solution. The succinated gelatin soft capsule developed by Tokai Capsule has been widely used from formulation of unsaturated fatty acids to herbal extracts.
Softness of the outer capsule shell and significantly increased solubility make the capsule chewable, allowing for easy and ready-to-take oral administration without water. Easily-chewable capsule with a soft capsule shell Can be taken without water Easy-to-take formulation achieved by flavoring the inner fill material NC-CAP technology prevents capsules from sticking to each other Maintains characteristics of regular capsules Oily complex can be processed into capsules at room temperature Ideal bioavailability can be achieved Content uniformity with high accuracy and precision Provides stability for compounds susceptible to oxidation Provides stability for compounds that are light sensitive 　 CSC Gly 30